第五章巴比妥类药物分析

《第五章巴比妥类药物分析》由会员分享，可在线阅读，更多相关《第五章巴比妥类药物分析（55页珍藏版）》请在文档大全上搜索。

1、一、掌握巴比妥类药物的化学结构与分析方法一、掌握巴比妥类药物的化学结构与分析方法 间的关系；掌握巴比妥、苯巴比妥、司可巴比间的关系；掌握巴比妥、苯巴比妥、司可巴比 妥及硫代巴比妥类药物的鉴别，巴比妥类药物妥及硫代巴比妥类药物的鉴别，巴比妥类药物 的银量法与溴量法测定的原理与方法。的银量法与溴量法测定的原理与方法。二、熟悉巴比妥类药物的紫外分光光度法。二、熟悉巴比妥类药物的紫外分光光度法。三、了解苯巴比妥的特殊杂质及其检查。三、了解苯巴比妥的特殊杂质及其检查。CCONHCONHCOR1R2123465巴比妥类药物结构通式巴比妥类药物结构通式表表5-1 常见巴比妥类药物及其结构常见巴比妥类药物及其

2、结构苯巴比妥苯巴比妥名称R1R2巴比妥巴比妥C2H5C2H5C2H5C6H5司可巴比妥司可巴比妥戊巴比妥戊巴比妥C2H5CH(CH2)2CH3CH3异戊巴比妥异戊巴比妥C2H5CH2CH2CHCH3CH3CH2CH=CH2CH(CH2)2CH3CH3硫喷妥钠硫喷妥钠C2H5CH(CH2)2CH3CH3（C2硫取代）CCCONONC OH5C2H5C2HH巴比妥5BarbitalCCCONONC OH5C2HH苯巴比妥PhenylbarbitalCCCONONC ONaCH2CHCH2CHCH3C3H7H司可巴比妥钠SecobarbitalCCCONONC ONaC2H5CHCH2CH2CH3C

3、H3H异戊巴比妥钠CNHCNHCOOOH5C2CH3(CH2)2CHCH3戊巴比妥戊巴比妥CCNHCNHOOOH5C2环己烯巴比妥环己烯巴比妥CCNCNHOOOH3CCH31,5,5-取代的巴比妥类药物 己琐巴比妥己琐巴比妥51硫喷妥钠HCCCONONCSNaC2H5CH3CH2CH2CHCH3NCCCNCOR2R1CCONHCONHCOR2R1CCONHCNCOOH+H-H+pK1=8CCONHCNCOR1R2O-+H+-H-OR2R1O-pK2=12（一）弱酸性（一）弱酸性NOOHHCON1RRCCC222HNHC2)3HC(4+oC+221RRCCCNOCHOOCNNON21RRCCCN

4、OONHCo2)3HC(HCH2)3HC(HCH3HNHC2)3HC(2+1、与钴盐的反应、与钴盐的反应部分离子化水-吡啶 +2NNCu2+OR2R1CCONHCNCO-22-+ SO42+CuNN+ CuSO4N + H-R2R1CCONHCONHCOR2R1CCONHCNCOOHCCONHCNCOR1R2OOR2R1CCONHCNCOCCONHCNCOR1R2ONNCu2、与铜盐的反应、与铜盐的反应ONa + AgNO3 + Na2CO3CCONHCNCOR1R2R2R1CCONNCOCAgONa + NaHCO3 + NaNO3ONa + AgNO3 R2R1CCONNCOCAgAgCO

5、CCONNCOR1R2Ag+ NaNO33、与银盐的反应、与银盐的反应R1R2OHHgNO3CCONCNCOR2R1CCONCONHCOHgNO3+ Hg(NO3)2CCONHCONHCOR1R2CCONCNCOHgNO3OHR2R1+ NH3 + H2O+-CCONCNCOHgOHO NH4 +HNO3R2R14、与汞盐的反应、与汞盐的反应CCONHCONHCOH5C2CH3(CH2)2CHCH3OCH3CHOOH+CH3(CH2)2CHH5C2CCONCONHCOCH3CH3CCOCNHCOH5C2CH3(CH2)2CHNOOHCHOCH3-H2O（戊巴比妥）240nm255nm13酸溶酸

6、溶液液9.9238nm287nm304nmHclNaOHIIONaONaCH3C3H7CHCCONHCNHCOCH2CHCH2I2CH2CHCH2CCONHCNHCOC3H7CHCH3+（司可巴比妥钠）（一）不饱和取代基的反应（一）不饱和取代基的反应-司可巴比妥司可巴比妥CCONHCONHCO+ 2KNO3 + H2SO4H5C2NO2O2NH5C2CCONHCONHCO+ K2SO4 + 2H2O（苯巴比妥）（二）芳香取代基的反应（二）芳香取代基的反应-苯巴比妥苯巴比妥PbSPb2H3C(CH2)2CHCCONHCNHCOH5C2S2+ PbSNaH5C2CCONHCNHCO2H3C(CH2