药物化学结构与代谢.

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1、RHOHRROHHOHHROHROHROHOH2GSHSGOHRXOHR重排生物大分子亲核基团X谷胱甘肽-S-转移酶环氧化物酶NHNHOONHNHOOOHNNOC4H9ONNOC4H9OOHNHNClClNHOOCSO2N(CH2CH2CH3)2NSRClCH2CH2CH2NMe2R=HR=OHOOHOHOHSGNCONH2CYP450NCONH2ONCONH2OHOH环氧化物酶RCCHRCCHRCHCORCHCORCH2NCORCOCHRCH2COOHRCH2CONH-Pr卟啉酶酶酶酶CH3COSO2NHCONHCH3CSO2NHCONHHOHS-(-)OOHOPhOOHRCCHR2R3HR

2、1OHCCHR=CH3R1=CH3,R2=OH,R3=HR=C2H5R1=C2H5,R2=H,R3=OHRNO2e-RNO2-e-22H+RNOe-H+ RNO He-H+RNHOHe-22H+RNH2O2 O2NNO2ONNHOHO（致癌）NHNOClRa_R=NO2b_R=NH2ONNHCONH2N2OONNHCONH2NHOH+ONNHCONH2NH2ONHNNHCONH2ONNHCONH2NHArNNAre-ArNNAre-H+2ArNHNHAre-2H+2ArNH2+ArNH2O2- O2.-.NNHSO2NNCOOHOHNNHSO2NH2+COOHOHNH2NCH2CH2CH2N(

3、CH3)2ONCH2CH2CH2N(CH3)2(C2H5)2NCSSCSN(C2H5)2(C2H5)2N-C-SHSCH3SOCH3CH3SCH3N2OCHCHOHNHCOCHCl2CH2OHN2OCHCHOHNHCOCOClCH2OHPrOHNHCOCH2OHCHCHN2OCOPrC Cl4CYP450Cl4C_.-Cl-Cl3C.H+e-O2C H Cl3:C Cl3Cl3C-O-O.BrCHClCF3e-Br-HC-CF3.e-H-CF2CClF-F-ClCH=CF2PrPrClCF3HCRHR H2CCF3ClBrCF3ClCHBrCF3ClCOH-Br-CF3COClPrOH2CF3

4、COPrCF3COOH(肝毒性)R - C O C R1R - O H+R1C O O HR - O N O2R - O H+H N O3R - O S O3HR - O H+H2S O4R - N H - O O C R1R - N H2+R1C O O HOON+(CH3)3OON+(CH3)3OHN+(CH3)3+COOHCOOHCOOHOACCOOHOH+AcOH琥珀酰胆碱阿司匹林NCH3HOOROO可卡因NH2CXOCH2CH2N(C2H5)2X=NHX=O普鲁卡因酰胺普鲁卡因CH3NHNHCH3ONNHClOCOCH3O丙胺卡因奥沙西泮O HO HOO HOO HC O O HOO